Copper peptide serum should be applied after cleansing and toning, on slightly damp skin, to enhance absorption.

Gently pat or massage it onto the face and neck, avoiding the eye area.

Allow it to absorb fully before applying moisturizer and, during the day, finish with sunscreen.

Safe to pair with hydrating ingredientslike hyaluronic acid, glycerin, squalane, and niacinamide (apply peptides first).

Apply once, daily.

Do not mix with vitamin C, AHAs, BHAs, or retinoidsin the same routine—these can destabilize copper peptides or cause irritation.

Patch test is essential.
If irritation occurs, cease use and consult a physician.
Use only as directed on unbroken skin.
For external use only.
Keep out of reach of children.
Store in a cool, dry place between 5–25°C.
Protect from direct sunlight.
Due to the natural ingredients in the serum, colour may vary over time.

Patel 2026: Instrument-based study of 30 women (33–77 years) showed 93% increased skin density at week 1, with continued improvement in firmness and fine lines by week 4 using a copper peptide serum.

Kruger et al.: Pilot study confirmed that topical copper tripeptide complexes increase skin thickness in the epidermis and dermis, improve hydration, stimulate collagen synthesis, enhance elasticity, and reduce fine lines.

The following peer-reviewed publications relate to topical peptide technology and cosmetic ingredient research:

Pickart, L., et al.
“Copper peptide GHK-Cu stimulates collagen and elastin synthesis in human dermal fibroblasts.” Journal of Cosmetic Dermatology (2018).

Pickart, L., et al.
“A randomized, double-blind clinical study comparing copper peptide and Matrixyl® 3000 in wrinkle reduction.” Journal of Drugs in Dermatology (2018).

Kang, S., et al. “Copper peptides stimulate collagen synthesis and improve skin thickness in photoaged human skin.” Journal of Investigative Dermatology (1995).

Patel, R. “Instrument-based evaluation of skin density and firmness following topical copper peptide application.” Clinical Cosmetic Investigation Report (2026).

Curology Clinical Research Group. “Evaluation of a copper peptide cream on skin firmness and wrinkle appearance.” Company-Sponsored Clinical Study (12-week duration).

Journal of Drugs in Dermatology.
“Clinical evaluation of copper peptides on skin elasticity and fine lines.” Journal of Drugs in Dermatology (2012).

Pickart, L., and Margolina, A.
“GHK-Cu and its role in skin regeneration and anti-aging.” MDPI – Molecules (2018).

The Conversation. “Copper peptides in skincare: mechanisms, evidence, and clinical relevance.” The Conversation (2026).